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KMID : 0388120060150010026
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Journal of Korean Society for the Study of Obesity
2006 Volume.15 No. 1 p.26 ~ p.31
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Effects of Voglibose and Glimepiride on Adipose Tissue and Metabolic Abnormalities in Patients with Newly Diagnosed Obese Type 2 Diabetes
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Park Jong-Suk
Kim Chul-Sik
Kim Hai-Jin
Park Jin-A
Ahn Chul-Woo
Cha Bong-Soo
Lim Sung-Kil
Kim Kyung-Rae
Lee Hyun-Chul
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Abstract
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Background: To compare the effects of voglibose and glimepiride on adipose tissue and metabolic abnormalities
in obese patients with newly diagnosed type 2 diabetes.
Methods: Total of 40 obese patients with newly diagnosed type 2 diabetes (BMI > 25 kg/m2) were included in this study. Study patients were randomized into voglibose group (n = 20) and glimepiride group (n = 20), where respective medication was administered for 12 weeks. We assessed the changes of biochemical parameters, body composition and serum adiponectin - 30 - body composition and serum adiponectin levels.
Results: The voglibose treated group achieved a significant decrease in BMI, total body fat mass, and percent body fat ( P< 0.05) after 12 weeks. A reduction in both subcutaneous and visceral abdominal adipose tissue area and VSR (visceral fat area / subcutaneous fat area) were noted only in the voglibose group ( P< 0.05). Serum lipid profiles were similar between the two groups, except for the decrease in triglyceride levels, which were significant only in the voglibose group ( P< 0.05). Serum adiponectin levels were increased only in the voglibose group ( P< 0.05).
Conclusions: In this study, voglibose showed to significantly decrease adipose tissue and improve adiponectin level.
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KEYWORD
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Adiponectin, Adipose tissue, Glimepiride, Voglibose
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